Xerostomia, commonly known as “dry mouth,” is a reported side effect of >1,800 drugs from >80 classes. This condition often goes unrecognized and untreated, but it can significantly affect patients’ quality of life and cause oral and medical health problems. Although psychotropic medications are not the only offenders, they comprise a large portion of the agents that can cause dry mouth. Antidepressants, anticonvulsants, anxiolytics, antipsychotics, anticholinergics, and alpha agonists can cause xerostomia. The risk of salivary hypofunction increases with polypharmacy and may be especially likely when ≥3 drugs are taken per day.